Red Copper Classified (Finished 05/06/2009 OP Updated)  

That's what I'm running into with my MSI P6N Diamond and 4 GTS 250s. The bottom PCIe slot is the very bottom slot and my cases all have the PSU right under the Mobo. I just started designing a home built case to have rooom for all 4 and design the case around AirFlow. I'll probably make it a dual System Box mainly wooden with Coolermaster Mobo Trays.