This or That
2x GTX 295 without a doubt. I've tried 2x GTX 295 and 3x GTX 280 and the 295s win in most games, and definitely in 3DMark Vantage, but the comparison wasn't exactly fair. The GTX 280 rig had a QX9770 running at 4.95 ghz. The Quad-SLI GTX 295 rig had an i7 965 overclocked to 4.5 ghz I believe. But still I like high 3DMark Vantage scores and both are amazing.
Yorkfield or Phenom II x4?